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Clindamycin/Tretinoin/NAD+ Combination Therapy

  • What is it? This is a combination therapy containing an antibiotic (clindamycin), a retinoid (tretinoin), and a form of vitamin B3 (NAD+). It’s used to treat acne, fine lines, wrinkles, and skin discoloration.
  • How to use: Wash your hands before and after applying. Apply a thin layer to your face and neck at bedtime or as directed by your doctor.
  • Dosage: The typical dose is a pea-sized amount of the combination gel or cream applied once daily at bedtime.
  • Important information:
    • It may take 3-6 months to see results. Continue using as directed.
    • Avoid getting it in your eyes, nose, mouth, or on sensitive areas. If contact occurs, rinse with water.
    • Minimize exposure to wind, cold weather, and the sun. Use a sunscreen with SPF 15 or higher and wear protective clothing when going outside.
    • You may experience temporary redness, itching, or flushing. If it persists, tell your doctor.
    • Tell your doctor if you have a history of Crohn’s disease, ulcerative colitis, antibiotic-related colitis, or are taking drugs that increase sun sensitivity.

Tips for use:

  • Cleanse your face with a gentle cleanser and lukewarm water. Pat dry.
  • Wait 20-30 minutes before applying the combination therapy.
  • Apply a moisturizer after the medication has absorbed to reduce dryness and irritation.
  • Don’t use other products containing clindamycin, erythromycin, tretinoin, or NAD+ while using this medication.

While the combination therapy works to combat acne and signs of aging, certain supplements can enhance your results. Here are some that definitely could help you:

  • Omega-3 Fatty Acids: These reduce inflammation, which can contribute to acne and skin aging. Find them in fatty fish, flaxseeds, walnuts, or take a supplement.
  • Probiotics: Beneficial bacteria in your gut play a role in your skin health. Take a probiotic or eat probiotic-rich foods like yogurt, kefir, kimchi, or sauerkraut.
  • Vitamin C: This antioxidant fights free radicals that damage skin. Increase your intake through citrus fruits, berries, leafy greens, or a supplement.
  • Zinc: This mineral aids in wound healing and fighting bacteria that cause acne. Include zinc-rich foods like oysters, beef, chicken, or fortified cereals in your diet.

General Tips

  • Consistency is key: Stick to your treatment routine even if you don’t see results right away. It can take 3-6 months.
  • Sun protection: Minimize sun exposure and use a broad-spectrum sunscreen with SPF 15 or higher daily. Wear a hat and protective clothing.
  • Moisturize: Apply a non-comedogenic moisturizer after the combination therapy to combat dryness. Look for a moisturizer containing hyaluronic acid, ceramides, or niacinamide.
  • Monitor your skin: Take progress photos monthly. Note any changes, including new acne, redness, or irritation.
  • Diet: Eat an anti-inflammatory diet rich in whole foods, fruits, vegetables, lean proteins, and healthy fats. Limit processed foods and sugar.
  • Stay hydrated: Drink plenty of water to keep your skin hydrated from the inside out.
  • Get enough sleep: Aim for 7-9 hours of sleep per night. Lack of sleep can lead to puffy, dull-looking skin.

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